The apoprotein of the MUC 1 mucin contains a transmembrane domain, a cytoplasmic domain, and an extracellular carbohydrate-rich domain. The extracellular domain is characterised by polymorphism with respect to the number of a 20 amino acid tandem repeat (VNTR polymorphism).
The CA15-3 EIA is based on two mouse monoclonal antibodies, Ma695 as catcher antibody recognising a sialylated carbohydrate epitope expressed on the MUC 1 antigen and Ma552 as tracer antibody targeting the PDTRPAPG region of the protein core.
The MUC 1 breast cancer mucin (CA15-3 antigen) is secreted from tumour cells and is a well-established serological marker for monitoring the clinical course of breast cancer patients.
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