Reach the highest step in sensitivity
INNO-LiPA CFTR is a multiparameter line probe assay, based on the reverse hybridization principle, for the simultaneous detection and identification of 8 large rearrangements and 6 mutations and their wild-type sequences in human whole blood, dried blood spots, and buccal brush samples.
For the detection and identification of all ACMG mutations the INNO-LiPA CFTR 19 and INNO-LiPA CFTR 17+Tn Update kits are both required to be tested (testing for 35 mutations, one polymorphism and three Tn variants).
Well-defined study cohorts prove that large rearrangements in the CFTR gene account for 16-26% of unidentified CF alleles in various populations.
Large rearrangements, of which large deletions are the most common type, have a high clinical relevance as they will always lead to a severe form of the disease in presence of another CF causing mutation.
This strip contains mutations that have a significant frequency in Italy, Bulgaria, Turkey and Hispanic Countries.
Features & Benefits
- The combination of the 2 strips, CFTR 19 and CFTR 17 + Tn Update covers the panel of CFTR mutations recommended by the ACMG/ACOG (23 mutations). The combination of these two strips can be tested in one trough.
- The CFTR Deletions + 6 strip:
- Detects the 8 most frequent large CFTR Deletions
- Detection of six (6) additional severe disease-causing mutations including the second most frequent mutation in the Turkish population (1677delTA)
- Provides an increased overall detection rate of up to 3.5%
- Only one amplification is needed
- One test procedure for the complete INNO-LiPA CFTR portfolio.
- Both INNO-LiPA CFTR Deletions + 6 and INNO-LiPA CFTR Italian Regional can be tested in the same strip trough.
- The test is fast and easy to perform, offers quick visual interpretation, and full results are obtained within one working day.
- Fully automated processing of the strips is possible using TENDIGO™, Auto-LiPA™ 48 and AutoBlot 3000H and interpretation via the LiRAS for LiPA Cystic Fibrosis Software.
- Objective manual processing and interpretation also available.
For more information, visit Fujirebio.com.